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INTRODUCTION Methotrexate (MTX) is a synthetic antimetabolite with many therapeutic indications, mainly anti-inflammatory and immunosuppressant at relatively low doses and antineoplastic at high doses.[ , ] MTX competitively inhibits dihydrofolate reductase, so decreasing tetrahydrofolate level leads to blocks the synthesis of purines, pyrimidines, DNA, ribonucleic acid, thymidylate, and proteins.[ , , ] It is well known that MTX is a hepatotoxic drug, and this leads to limitation of its clinical use

Injectable BPC-157 is often recommended for: Because the peptide can be injected close to the affected area, it offers a level of precision that oral and topical forms simply cannot match

Therefore, excessive antioxidant intake may induce RS, potentially resulting in unforeseen detrimental effects on sperm function [12]

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